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Copyright 2006 Mary Desaulniers
It is New Year's Eve. You have one drink, then another, then a
third. You used to be able to chug down 6 drinks without
consequences. But lately, you've noticed that things are a bit
different. Before dinner is over, you are wobbly; your speech
slurs. Before the night is over, you are spread
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Alcohol withdrawal syndrome is intermediated by a mixed bag of
mechanisms. The mind maintains neurochemical symmetry through
repressive and excitant neurotransmitters. The principal
inhibitory neurotransmitter is gamma-aminobutyric acid (GABA),
that works through the GABA-alpha (GABA-A) neuroreceptor. One of
the major excitant neurotransmitters is glutamate, which behaves
through the N-methyl-D-aspartate (NMDA) neuroreceptor.
Alcohol raises the outcome of GABA on GABA-A
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